Iron-Deficiency Anemia is the major cause of illness and death in adolescent girls in developing countries, weakening an already vulnerable population and contributing to the cycle of poverty and gender inequality. Unfortunately, attempts to address iron-deficiency anemia in lower- and middle-income countries (LMICs) are often limited by bottlenecks in access, distribution, and community and cultural acceptance. These issues commonly bring well-funded, national-scale global public health initiatives to a halt. By utilizing naturally growing turkey berries, this initiative mobilizes a ubiquitously accessible, culturally integrated, and uniquely bioavailable plant-based iron supplementation solution to address iron-deficiency anemia in LMICs. In a first-of-its-kind randomized-controlled trial held in Ahafo, Ghana, turkey berry–fortified biscuits outperformed UNICEF’s nationwide initiative by a factor of triple, six times faster, and at a cost of roughly US$15 per adolescent girl over a month and a half.