Periodontitis, impacting 50 percent of adults in the United States, is a chronic destructive inflammatory disease that affects the tooth-supporting tissues. The current treatments in the market mainly deal with bacteria elimination, and the regeneration of periodontal tissues remains a challenge. Sal-Patch offers a periodontal microarray patch that enhances the local effectiveness and sustainably delivers therapeutics for inhibiting the bacteria growth while modulating immune cell functions. Together, it both repairs the receding gum line and reverses bone degeneration. Periodontitis is especially prevalent in impoverished communities, and Sal-Patch wants to mitigate the issue with its low-cost, accessible dental patch.
According to the National Cancer Institute, the cost of cancer care will reach $246B in 2030. NurLabs is transforming the diagnosis and treatment paradigm for cancer through a patented liquid biopsy platform, so we may treat cancer earlier, when survival rates are the greatest and treatment is the least expensive. Our innovation is the nexus of materials science and bioinformatics, bringing a fresh perspective to a $246B problem.
Donor human milk (DHM) is key to helping infants in neonatal intensive care units grow, fight infection, and thrive. Existing methods of DHM preparation struggle to create products of high nutritional value while remaining affordable for widespread use. LacNation brings a new pasteurization technique to the table that more selectively eliminates pathogens while sparing important nutrients for growth and infection prevention. Moreover, this system has the potential to reduce costs of safe DHM production and allow hospitals to expand coverage to more infants thereby.
Sickle Cell Disease is said to affect 30 million people worldwide, including 100,000 people in the United States. For most of the world, it is too expensive to diagnose, leading to unnecessary childhood deaths. Even in high-income countries, SCD is hard to monitor and even harder to treat. KovaDx provides an AI-based diagnostic and monitoring device for sickle cell and other hemolytic anemias combining 3D phase imaging with deep learning. The point-of-care device can be influential in low-resource areas by affordable and quick tests. Monitoring also aids in the process of treating and minimizing health care costs.
Catena has developed a novel platform to create cures for diseases previously thought incurable. Catena’s groundbreaking technology enables the attachment of proteins using only native amino acids, allowing for the rapid production of exciting new protein and cell-based therapies. We plan to utilize this technology to bring massive breakthroughs in autoimmune disorders, oncology, and vaccine development.
There is a dire need to invest in intermediate care bridging from the resuscitative efforts in the Emergency Departments and the supportive care offered by the intensive care units in Uganda. There is a high prevalence of missed opportunities for patients requiring advanced ventilatory support in ICUs at Emergency Units. This is due to there being only 55 Intensive Care beds with Mechanical Ventilators for a population of close to 40 million in Uganda. The Automated Ambu Bag System (AABS) is designed to provide controlled ventilatory support to patients with respiratory failure. The project is aimed at utilizing existing and relatively affordable bagging technology providing vital features of an Advanced Ventilatory Support System. The device will offer intermediate-advanced respiratory support to patients in the transition to the ICU, which usually takes up to one week in our setting.
Stroke rehabilitation is often inaccessible, expensive, and requires a lot of scarce, highly trained professionals. By harnessing the processing power of smartphones in combination with recent advances in artificial intelligence, NeoMotion AI will be able to improve rehabilitation at a worldwide scale. NeoMotion AI is run on AI-based pose estimation algorithms and it optimizes them for usage on smartphones without internet connection. Using a smartphone camera and this software, the solution involves tracking the coordinates of every joint of the upper and lower limbs, proving patients, rehabilitation specialists, and physicians with a tool to track patient’s rehabilitation progress over time. At a later stage, performing rehabilitation exercises in front of a smartphone would allow patients to receive personalized exercise corrections or new and adaptive exercises suggestions. NeoMotion AI can provide an engaging rehabilitation experience for stroke patients through a social platform, creating a sense of community, and a more integrated management system for physical therapists or physicians.
In the community of Mabinju, Kenya, 3,500 people have limited access to clean water for agriculture and basic needs. Lake Victoria, the main water source in Siaya county where Mabinju is located, is infested with water hyacinth and contaminated with fluoride and traces of copper (II) and zinc (III), which cause rapid spread of disease throughout the region. The Mabinju Borehole Project will address the lack of accessible clean water in the region by installing a borehole that uses a solar-powered pump to extract groundwater. The project aims to provide enough potable water for the community’s needs. With this accessibility, the residents will no longer have to rely on polluted, stagnant water from Lake Victoria. The rate of water-borne illnesses, such as cholera and dysentery, will decrease and the community’s income and food, which relies substantially on their agriculture, will further thrive with an abundance of clean and accessible water.
The mortality rate for neonates in Uganda with Gastroschisis is 98% compared to high-income countries with less than 4%. Gastroschisis is a congenital anomaly birth defect in which abdominal organs protrude through a small opening right of the umbilical cord. The difference in the survival rate between low-income countries and high-income countries is largely caused by failure to keep the neonates hydrated, nourished, and infection-free while their bowel is outside the abdomen. This is because silo-bags used to put the bowel back into the baby’s abdomen cost approximately $240 which is 140% of the average monthly income in Uganda. The Gastro-Bag Project has developed and tested a low-cost silo-bag for treatment and management of Gastroschisis using locally available materials in Uganda at a cost of less than $5. The Gastro-Bag Project intends to demonstrate feasibility and improvements in quality, efficacy, operability, costs, and accessibility of Gastroschisis to improve human health.
