The mortality rate for neonates in Uganda with Gastroschisis is 98% compared to high-income countries with less than 4%. Gastroschisis is a congenital anomaly birth defect in which abdominal organs protrude through a small opening right of the umbilical cord. The difference in the survival rate between low-income countries and high-income countries is largely caused by failure to keep the neonates hydrated, nourished, and infection-free while their bowel is outside the abdomen. This is because silo-bags used to put the bowel back into the baby’s abdomen cost approximately $240 which is 140% of the average monthly income in Uganda. The Gastro-Bag Project has developed and tested a low-cost silo-bag for treatment and management of Gastroschisis using locally available materials in Uganda at a cost of less than $5. The Gastro-Bag Project intends to demonstrate feasibility and improvements in quality, efficacy, operability, costs, and accessibility of Gastroschisis to improve human health.